Jon Arbuckle buys a second pet, a dog named Odie. However, Odie is then abducted and it is up to Jon's cat, Garfield, to find and rescue the canine.
Garfield, the fat, lazy, lasagna lover, has everything a cat could want. But when Jon, in an effort to impress the Liz - the vet and an old high-school crush - adopts a dog named Odie and brings him home, Garfield gets the one thing he doesn't want. Competition. One night Odie run away and gets dog-napped after Garfield locks him outside. Garfield, in an out of character move, goes to search for and rescue Odie with the help of a variety of animal friends along the way.

former , Garfield ( Bill Murray voice ) life is perfect , it is happily immersed in their favorite three things : high-calorie foods , long lethargy and an unlimited number of pet owner , Jon Abu library , but the Abu library has just adopted a puppy Audi ( to Odie ' ) put all total destruction , and now they want to share food and pet , more over , this energetic dog Garfield 's dreams of sleep come to naught . Now, in the Garfield each broken dream , he imagined this nasty guy can be out of their own lives . Perhaps telepathy effect of Garfield , a puppy is really missing in one night , but it really disappeared from the side , Garfield master lonely , also animate the first time to feel lonely and they should bear the responsibility , through the investigation , which Audi is a mean of trainer kidnapped , and now Garfield to say goodbye to a TV and a gourmet , in order to rescue his partner to show the skill of obesity ......