Set in Catalonia, Painless weaves two stories: in one, starting during the Spanish Civil War and running through to the '60s, an asylum attempts to rehabilitate children who feel no pain, by teaching them physical suffering. In the second, in the present time, a brilliant neurosurgeon who needs a bone marrow tranplant, discover this dark past when he searches for his biological parents.

这部由西班牙和法国合拍的惊悚片交织地讲述了两个时空的故事:西班牙内战期间前夕,一些儿童得了一种病-失去疼痛的感觉，并因间接地伤害身边的人而被关在了类似精神病院的地方,直到一位护士请来了德国的儿童专家Holzmann教授(Derek de Lint饰)才改变孩子们的处境,他试图教育他们,希望有一天这些孩子能过上正常的生活,但古板,自傲的院长以及一些老护士的恶劣行为,一个叫Benigno的孩子越发失去人性...而在另一个时空,失去妻子的医生David(Àlex Brendemühl饰),患上了白血病,在请求父母做骨髓移植后不久发疯似地开始调查自己的身世...