Dr. Kaede Kojima (Matsushima Nanako) is now the staff leader at Minato University Hospital's Emergency and Critical Care Center. It's been a month since she took that position. She's calm and precise in her role as staff leader, but she doesn't let others get close to her. The relationship between staff members is awkward because of this. Others can't figure out why Hospital Director Tooru Mogami (Danta Yasunori) put Kaede Kojima in her position.

One day, a patient's family asks the hospital to stop a donor transplant. Hospital Director Tooru Mogami calls Dr. Kaede Kojima in for a meeting. When Kaede Kojima gets there, Tooru Mogami and Yasuhiro Sugiyoshi (Tezuka Toru) wait for her. Yasuhiro Sugiyoshi complains about the cancellation of the donor transplant and blames staff members for not persuading the patients' family enough. Tooru Mogami then reveals that he invited donor transplant specialist Dr. Mamoru Natsume (Tokito Saburo).

Around this time, tragedy strikes with multiple stabbings and an explosion. The Emergency and Criticial Care Center is inundated with injured victims. Chaos ensues as the staff fails to work together and the doctors do not cooperate or communicate with each other.