"Saijou no Meii" follows the story of a young genius surgeon named Saijou Mikoto who was born with a bad heart, however, since he was under the care of the leading Japanese heart surgeon, Shindou Mamoru, he survived his illness. In return, Saijou himself became a surgeon, and in the process, eventually became the greatest pediatric surgeon in the world.

Mikoto Saijou was born with a heart disorder - the two great vessels to his heart were crossed. At the ago of 10, Mikoto Saijou underwent a complicated surgery procedure performed by the great pediatric heart surgeon Dr. Mamoru Shindo at the Saihama Medical University Hospital to overcome his heart disorder. As a young adult, Mikoto Saijou was inspired by the work of Dr. Mamoru Shindo and, from that moment on, decided to become the greatest pediatric surgeon the world has ever known.